Henry Buhl has long been fascinated by artwork depicting images of hands, and he has spent decades filling his sprawling downtown Manhattan loft with hand-themed sculptures by Rodin, Botero, Picasso and others.

But after nearly three decades, he is ready to hand over the keys. The 89-year-old Mr. Buhl, a photographer and philanthropist, is listing his four-bedroom Soho loft for $19 million with Richard Ziegelasch and Victoria Vicuna of Brown Harris Stevens. Mr. Buhl combined two units to create the roughly 7,100-square-foot…



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